Young Plasma

Patient-Driven Research

 

A patient-funded clinical study is being designed that will be open for members of our private association. 

 

The project will provide thoroughly screened plasma from donors in their early 20s by medical groups initially in South Florida, and eventually in other states.

 

This comparison study will evaluate the following three approaches:

 

1)   Plasma Replacement – Remove plasma from seniors and replace with thoroughly screened plasma from donors in their early 20s

 

2) Plasma Infusion – Infuse seniors with thoroughly screened plasma from donors in their early 20s (no plasma removal).

 

3) Plasma Exchange – Remove plasma, replace with saline and albumin followed by IgG for immune system.

 

Each participant’s unique situation will be evaluated by the study site physician and principal investigator to select the option that best serves their individual age management objectives, along with affordability considerations.

 

Open-Source Results

 

The study will assess the effects of differing young plasma approaches and rapidly communicate results to our community.

 

Costs for therapies and objective measures of testing biological aging are to be covered by study participants. 

 

The intention is to make the therapies accessible and affordable to everyone at the lowest possible cost.

 

There is evidence these interventions may assist in certain kinds of early-stage dementias.

 

Some references are on the bottom of this page.

 

The Young Plasma Costs

 

Creating an initiative like this will depend largely on what is paid to select extremely healthy young donors, thoroughly screening of young donor lifestyle and their blood, medical staffing, overhead, and number of participants.

 

The best estimates of costs as of today are listed below.  Note: These are not yet firm prices.  This is a new initiative and there will be a learning curve for those involved.

 

The costs below cover collecting plasma (there are many steps and costs to evaluate extremely healthy donors, test and collect), physician, infusion/apheresis nurse or specialist as required, supplies and some others.

 

Note: the prices below are for these experimental interventions and do not include necessary biomarker testing (covered after this).

 

These estimates are plus or minus about 20%

·    Plasma Replacement – Remove plasma from seniors and replace with thoroughly screened plasma from donors in their early 20s 1 liter (fair expected effect) – Estimated $6,071

2 liters (good expected effect) – Est. $8,771

3 liters (best expected effect – Est. cost $12,121

 

·    Plasma Infusion – Infuse seniors with thoroughly screened plasma from donors in their early 20s (no plasma removal).

1 liter (fair expected effect) – Est. $3,475

2 liters (good expected effect) – Est. $6,025

3 liters (best expected effect – Est. $8,900

 

·    Plasma Exchange – Remove plasma, replace with saline and albumin followed by IgG for immune system.

Est. $3523      

 

Biomarker Test Options

 

Some no-cost cognitive and physical tests will be used to keep costs to a minimum.

 

Biomarker lab tests to measure baseline and two follow-up tests range from $576 to $949 for each test panel. There are three test panels needed, one pre-treatment and two follow-ups. 

 

The program is planned to begin in South Florida in April-May 2024, and in other states after.  California and New York will be among the first, and others will depend upon prospective participant input, especially from Age Reversal Network members.

 

If you are interested in participating, contact

Johnny Adams

Aging Intervention Foundation

1-954-493-3414

JAdams@AgingIntervention.org

Background:

https://www.aginginterventionfoundation.org/JohnnyAdamsTPRTPITPE.pdf

 

And if you are a physician or have a clinic that would like to provide these valuable therapies to your patients, don't hesitate to make contact.

 

References

Webinar

"Young Blood for Old Brains and the Quest to Slow Brain Aging"

Tuesday, February 27, 2024 11:30 AM Eastern Standard

 

Speaker: Tony Wyss-Coray, Ph.D.

D.H. Chen Prof. of Neurology & Neurological Sciences and Director, Phil and Penny Knight Initiative for Brain Resilience, Stanford University

 

Registration link:

https://event.on24.com/wcc/r/4468137/3F2C156E0118D85CC0C5C09415C2B073?partnerref=eblast3 

 

 

Clinical Trials

https://clinicaltrials.gov/search?term=young%20plasma 

 

Research

Cognitive/Dementia/Alzheimer's

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172595/   

 

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439869/  

 

Young Blood Plasma Administration to Fight Alzheimer's Disease?

https://www.liebertpub.com/doi/10.1089/rej.2017.1940 

 

Platelet factors attenuate inflammation and rescue cognition in ageing

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468395/ 

 

Young blood plasma reduces Alzheimer's disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278124/ 

 

PubMed search

https://pubmed.ncbi.nlm.nih.gov/?term=young%20plasma%20dementia&page=3 

 

 

General Aging

Aging and age-related diseases with a focus on therapeutic potentials of young blood/plasma

https://link.springer.com/article/10.1007/s00210-023-02657-5 

 

Circulating plasma factors involved in rejuvenation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746393/ 

 

Plasma-Based Strategies for Therapeutic Modulation of Brain Aging

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694331/ 

 

Plasma from Young Rats Injected into Old Rats Induce Antiaging Effects

https://www.liebertpub.com/doi/10.1089/rej.2020.2354  

 

The effect of aging on the bone healing properties of blood plasma

https://www.injuryjournal.com/article/S0020-1383(21)00426-5/fulltext  

 

Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522807/  

 

Undulating changes in human plasma proteome profiles across the lifespan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062043/ 

 

Old plasma dilution reduces human biological age: a clinical study

https://link.springer.com/article/10.1007/s11357-022-00645-w 

 

PubMed search

https://pubmed.ncbi.nlm.nih.gov/?term=young+plasma+aging  

 

 

If you are interested in participating, contact

Johnny Adams

Aging Intervention Foundation

1-954-493-3414

JAdams@AgingIntervention.org

Background:

https://www.aginginterventionfoundation.org/JohnnyAdamsTPRTPITPE.pdf